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pentobarbital will decrease the extent or effect of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.pentobarbital will reduce the level or impact of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with potent CYP3A4 inducers is just not propo